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Диагностика, ремонт и техобслуживание автомобилей в Санкт-Петербурге
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We end one to POF is enriched towards the nascent RNAs transcribed out-of genes for the fourth chromosome and that it creates expression efficiency because of the enhancing the amount of chromosome 4 transcripts. Additionally, shown family genes in certain HP1-rich places, such as the pericentromeric regions as well as the last chromosome, showcase improved transition pricing, i.e., the fresh new RNA encoded off family genes on these nations uses less time regarding the nuclei than simply really does those of family genes during the regular euchromatic nations.

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Within the Drosophila melanogaster, two chromosome-wider compensatory assistance was characterized: the MSL cutting-edge, and therefore needs and you can stimulates the term of X chromosome inside males, and you may POF, and this needs and you will builds the word of one’s last chromosome (34, 66). It’s been hypothesized that the MSL advanced generates term by facilitating transcriptional elongation, and that hypothesis is recently verified experimentally (32). Here, i have made use of RNA immunoprecipitation and transcriptome profiling strategies to subsequent explain the fresh new mechanism by which POF builds gene phrase. (далее…)